Dehydrothermal Treatment로 제작한 흡수성 콜라겐 골유도재생술 차단막
Absorbable Guided Bone Regeneration Membrane Fabricated from Dehydrothermal Treated Porcine Collagen
방강미, 정한울, 김성포, 양은경, 김기호, 김성민, 김명진, 장정원, 이종호,
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방강미 ( Bang Kang-Mi ) - 서울대학교 치의학대학원 구강악안면외과학교실
정한울 ( Choung Han-Ul ) - 서울대학교 치의학대학원 구강악안면외과학교실
김성포 ( Kim Sung-Po ) - 바이오랜드연구소
양은경 ( Yang Eun-Kyung ) - 바이오랜드연구소
김기호 ( Kim Ki-Ho ) - 바이오랜드연구소
김성민 ( Kim Soung-Min ) - 서울대학교 치의학대학원 구강악안면외과학교실
김명진 ( Kim Myung-Jin ) - 서울대학교 치의학대학원 구강악안면외과학교실
장정원 ( Jahng Jeong-Won ) - 서울대학교 치의학연구소
이종호 ( Lee Jong-Ho ) - 서울대학교 치의학대학원 구강악안면외과학교실
KMID : 0360120110330020112
Abstract
Purpose: Collagen membranes are used extensively as bioabsorbable barriers in guided bone regeneration. However, collagen has different effects on tissue restoration depending on the type, structure, degree of cross-linking and chemical treatment. The purpose of this study was to evaluate the inflammatory reaction, bone formation, and degradation of dehydrothermal treated porcine type I atelocollagen (CollaGuideⓡ) compared to of the non-crosslinked porcine type I, III collagen (BioGideⓡ) and the glutaldehyde cross-linked bovine type I collagen (BioMendⓡ) in surgically created bone defects in rat mandible.
Methods: Bone defect model was based upon 3 mm sized full-thickness transcortical bone defects in the mandibular ramus of Sprague-Dawley rats. The defects were covered bucolingually with CollaGuideⓡ, BioMendⓡ, or BioGideⓡ (n=12). For control, the defects were not covered by any membrane. Lymphocyte, multinucleated giant cell infiltration, bone formation over the defect area and membrane absorption were evaluated at 4 weeks postimplantation. For comparison of the membrane effect over the bone augmentation, rats received a bone graft plus different covering of membrane. A 3×4 mm sized block graft was harvested from the mandibular angle and was laid and stabilized with a microscrew on the naturally existing curvature of mandibular inferior border. After 10 weeks postimplantation, same histologic analysis were done. 원고접수일 2010년 9월 20일, 게재확정일 2011년 1월 4일 책임저자 이종호 (110-749) 서울시 종로구 연건동 28번지, 서울대학교 치의학대학원 구강악안면외과학교실 Tel: 02-2072-2630, Fax: 02-766-4948, E-mail: leejongh@snu.ac.kr RECEIVED September 20, 2010, ACCEPTED January 4, 2011 Correspondence to Jong-Ho Lee Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University 28, Yeongun-dong, Chongro-gu, Seoul 110-749, Korea Tel: 82-2-2072-2630, Fax: 82-2-766-4948, E-mail: leejongh@snu.ac.kr CC This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Results: In the defect model at 4 weeks post-implantation, the amount of new bone formed in defects was similar for all types of membrane. Bio-Gideⓡ membranes induced significantly greater inflammatory response and membrane resorption than other two membranes; characterized by lymphocytes and multinucleated giant cells. At 10 weeks postoperatively, all membranes were completely resorbed.
Conclusion: Dehydrotheramal treated cross-linked collagen was safe and effective in guiding bone regeneration in alveolar
키워드
Guided bone regeneration; Type I collagen; Dehydrothermal treatment
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